Health For More » Alternative Medicine
Dose grapefruit juice really increase the effects of Oxycodone?
(4 posts)-
Posted 2 years ago # -
Yes, is true.
Recently some researchers have shown that furanocoumarins rather than flavonoids are the ingredients causing the various drug interactions.Drugs that may be affected include oxycodone, midazolam, ciclosporin, lovastatin, methadone, dextromethorphan, simvastatin, pravastatin, felodipine, sildenafil (Viagra) and caffeine, as well as a number of antihistamines including astemizole and terfenadine.
Some Benzodiazepines have also been reported to increase both the bioavailability of Diazepam and greatly slow the rate of metabolisation. An easy way to tell if a medication may be affected by grapefruit juice is by researching whether another known CYP3A4 inhibitor drug is already contraindicated with the active drug of the medication in question. Examples of such known CYP3A4 inhibitors include cisapride (Propulsid), erythromycin, itraconazole (Sporanox), ketoconazole (Nizoral), and mibefradil (Posicor)[citation needed].
The flavonoid existing in highest concentration in grapefruit juice is naringin, which in humans is metabolised to naringenin. Other flavonoids exist in grapefruit juice in lower concentrations as well. Orange juice does not contain naringin in as high a concentration, instead containing hesperetin. It is sometimes recommended as a substitute. Juice of limes and Seville oranges can also inhibit drug metabolism, however, as can apple juice with some drugs
Posted 2 years ago # -
ask a pharmacist.
Posted 2 years ago # -
Yes if you snort it!
Posted 2 years ago #
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